It's funny you ask this question. I just recently had an eye exam for new contact and asked the Doc. His response was that he advises not to were the contacts 24/7 for the month because the contacts need CO2, meaning for you to blink. so for a night it will not harm you, but it is healthier to take them out when you are asleep. Maybe some eye drops will help you until you finish work, if that may be possible for you to do. Good luck.