First thing in the morning put them on and LEAVE THEM ON if you don't you will never get used to them. If , while you have them on, you get a headache pop some Tylenol or your remedy of choice and by the afternoon you will see a major improvement. The reason for this is overnight your eyes have a chance to relax after being stressed all day and will be able to adapt to the new RX alot easier. Hope this has helped.